Browsing by Author "Daniel Comins, Member"
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- Applications of [2+2+2] Cyclotrimerization Reactions and Light-Cleavable Groups in the Generation of Biologically Active Molecules.(2012-08-03) Zou, Yan; Alexander Deiters, Chair; Christian Melander, Member; Joshua Pierce, Member; Daniel Comins, Member; Robert Beichner, Graduate School Representative
- Controlling Bacterial Pathogenic Behaviors using Indole-containing Small Molecules.(2014-10-16) Minvielle, Marine Josiane; Christian Melander, Chair; Daniel Comins, Member; Gavin Williams, Member; John Cavanagh, Member
- Development of New Methodologies for the Synthesis of Alkaloids and Light-Cleavable Groups.(2012-06-26) McIver, Andrew Louis; Alexander Deiters, Chair; Daniel Comins, Member; Jonathan Lindsey, Member; Christian Melander, Member; Nanette Nascone-Yoder, Member
- Development of Novel Small Molecules for Combating Infectious Disease.(2013-04-17) Lindsey, Erick Allen; Christian Melander, Chair; Gavin Williams, Member; Reza Ghiladi, Member; Daniel Comins, Member; David Ritchie, Graduate School Representative
- Novel Approaches for the Construction of Nitrogen and Sulfur Containing Heterocycles.(2015-11-04) Lewandowski, Berenice Lemercier; Joshua Pierce, Chair; Christian Melander, Member; Daniel Comins, Member; Gavin Williams, Member; Brian Matthews, Graduate School Representative
- Progress Towards the Total Synthesis of Pentacyclic Guanidinium Alkaloids.(2016-04-29) Moazami, Yasamin; Joshua Pierce, Chair; Christian Melander, Member; Daniel Comins, Member; Gavin Williams, Member; Brian Matthews, Graduate School Representative
- Small Molecule Control of Bacterial Virulence.(2012-06-18) Bunders, Cynthia Ann; Christian Melander, Chair; Jerome Cuomo, Graduate School Representative; Daniel Comins, Member; Gavin Williams, Member; Reza Ghiladi, Member
- Small Molecule Suppression of Antibiotic Resistance Mechanisms.(2013-12-12) Harris, Tyler Lee; Christian Melander, Chair; Gavin Williams, Member; Daniel Comins, Member; Alexander Deiters, Member; David Ritchie, Graduate School Representative
- Structure-Bioactivity Relationship Study on the Scaffold of 2-Aminoimidazole.(2014-03-05) Su, Rui; Christian Melander, Chair; Jonathan Lindsey, Member; Daniel Comins, Member
- Synthesis and Analysis of Mechanism Based Inhibitors of Juvenile Hormone Epoxide Hydrolase from Insect Trichoplusia ni(2002-02-25) Fetterolf, Brandon J; Russell J. Linderman, Chair; Edmond Bowden, Member; Michael Boyette, Member; Daniel Comins, Member; Binghe Wang, MemberThe research presented here entails a multi-disciplinary advance at understanding the role of juvenile hormone epoxide hydrolase in the metabolism of juvenile hormone in last stadium Trichoplusia ni. The work combines synthetic organic chemistry and biochemistry. A series of juvenile hormone analogs have been synthesized and their effectiveness to inhibit insect JHEH has been ascertained. Some of the key elements in the synthetic sequence for the fluorinated compounds include chemoselective oxidation of a primary alcohol in the presence of an alpha-fluorinated alcohol, introduction of a geminal difluoro group via a Reformatsky reaction or use of the DAST reagent, and selective nucleophilic and electrophilic epoxidation reactions. The synthesis of some of the non-fluorinated compounds employed regio-selective opening of an epoxide, Sonogashira palladium catalyzed cross coupling, nucleophilic epoxidation, and a variety of protecting group manipulations. Of all the inhibitors tested, the alkene 10 was the most effective alternative substrate with an I50 of 4.29 mM, slightly more potent than the benchmark MEMD. We also found that the introduction of fluorine increased the potency of the inhibitors compared to the non-fluorinated analogs. Lastly, inhibitor 5 provided insight to support a novel mechanism based inhibition of juvenile hormone epoxide hydrolase by formation of a tetrahydrofuran intermediate.
- The Synthesis and Biological Examination of 5-Membered Nitrogen-Based Heterocycles.(2015-01-06) Furlani, Robert Edward; Christian Melander, Chair; Michael Schulman, Graduate School Representative; Joshua Pierce, Member; Daniel Comins, Member; Gavin Williams, Member
- Synthesis of Light-Activated Nucleotides and Unnatural Amino Acids for Biological Applications.(2013-06-07) Uprety, Rajendra; Alexander Deiters, Chair; Daniel Comins, Member; Christian Melander, Member; Jonathan Lindsey, Member; Donald Brenner, Graduate School Representative
- Synthesis of Photo/Chemical-Activated Nucleosides and Unnatural Amino Acids.(2014-05-12) Liu, Qingyang; Christian Melander, Co-Chair; Alexander Deiters, Co-Chair; Daniel Comins, Member; Gavin Williams, Member; Matthew Koci, Graduate School Representative
- Synthesis of Unnatural Amino Acids for Protein Labeling and Activation.(2014-06-06) Torres, Jessica; Christian Melander, Co-Chair; Alexander Deiters, Co-Chair; Daniel Comins, Member; Gavin Williams, Member; David Lalush, Graduate School Representative
- Synthetic Metallobacteriochlorins with Site-specific Isotopic Substitution for Probing Photosynthetic Function.(2013-12-04) Chen, Chih-Yuan; Jonathan Lindsey, Chair; Daniel Comins, Member; Jerry Whitten, Member; David Shultz, Member; Cynthia Hemenway, Graduate School Representative
- Synthetic Methodology to Address What Makes Chlorophylls Green.(2012-02-28) Mass, Olga; Jonathan Lindsey, Chair; Daniel Comins, Member; David Shultz, Member; Reza Ghiladi, Member; Robert Bardon, Graduate School Representative
