Electrospinning Chitosan-based Nanofibers for Biomedical Applications

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dc.contributor.advisor Dr. Wendy Kruase, Committee Chair en_US
dc.contributor.advisor Dr. Russell Gorga, Committee Member en_US
dc.contributor.advisor Dr. Lucian Lucia, Committee Member en_US
dc.contributor.advisor Dr. Sam Hudson, Committee Member en_US
dc.contributor.author Queen, Hailey en_US
dc.date.accessioned 2010-04-02T17:52:35Z
dc.date.available 2010-04-02T17:52:35Z
dc.date.issued 2006-11-14 en_US
dc.identifier.other etd-06132006-092319 en_US
dc.identifier.uri http://www.lib.ncsu.edu/resolver/1840.16/13
dc.description.abstract Chitosan-based, defect free, nanofibers with an average diameter between 60 and 120 nm were fabricated via electrospinning a blended solution of low molecular weight chitosan (LMWC) and polyethylene oxide (PEO). Several solution parameters such as acetic acid concentration, polymer concentration, and polymer molecular weight were investigated to optimize fiber consistency and diameter. These parameters were evaluated using the rheological properties of the solutions as well as the visual images produced by scanning electron microscopy (SEM) after electrospinning the solutions. Pure chitosan fibers were not able to be created due to highly viscous solutions that lacked the polymer concentration required to successfully produce fibers via electrospinning. Three molecular weights of chitosan were evaluated to find the molecular weight that would support the optimal amount of chain entanglement, polymer concentration, and viscosity required for electrospinning. The chitosan with the lowest molecular weight (150,000 Da) allowed for the greatest concentration of polymer in solution without producing a solution viscosity that could not be overcome by an electric field. SEM imaging demonstrated that generally as total polymer concentration increased, the number of beads decreased; and as chitosan concentration increased, fiber diameter decreased. PEO-chitosan blends demonstrating a time dependent separation in solution; as a result blended solutions were able to be electrospun with the weakest electric field and the least amount of complications when solutions were electrospun within 24 hours of initially being blended. The addition of NaCl created a charge shielding effect that reduced the time dependent effect. Predominately chitosan-based, fibers with an average diameter of approximately 100 nm were also successfully electrospun onto a preexisting polysaccharide film used in biomedical applications. Electrospinning upon the biomedical film allowed for the removal of the electrospun nanomesh from the collector plate with the nanofibers and mesh structure intact. The bicomponent electrospun nanomesh created in this study is of particular interest in tissue engineering and wound healing applications. en_US
dc.rights I hereby certify that, if appropriate, I have obtained and attached hereto a written permission statement from the owner(s) of each third party copyrighted matter to be included in my thesis, dissertation, or project report, allowing distribution as specified below. I certify that the version I submitted is the same as that approved by my advisory committee. I hereby grant to NC State University or its agents the non-exclusive license to archive and make accessible, under the conditions specified below, my thesis, dissertation, or project report in whole or in part in all forms of media, now or hereafter known. I retain all other ownership rights to the copyright of the thesis, dissertation or project report. I also retain the right to use in future works (such as articles or books) all or part of this thesis, dissertation, or project report. en_US
dc.subject nanofibers en_US
dc.subject chitosan en_US
dc.subject electrospinning en_US
dc.subject surgical adhesion en_US
dc.title Electrospinning Chitosan-based Nanofibers for Biomedical Applications en_US
dc.degree.name MS en_US
dc.degree.level thesis en_US
dc.degree.discipline Textile Engineering en_US

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