High Capacity Heat Exchangers for Recirculating 18F Radionuclide Production Targets

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dc.contributor.advisor J.M. Doster, Committee Chair en_US
dc.contributor.advisor T. Gerig, Committee Member en_US
dc.contributor.advisor M. Haider, Committee Member en_US
dc.contributor.advisor B. Wieland, Committee Member en_US
dc.contributor.advisor M. Bourham, Committee Member en_US
dc.contributor.author Newnam, Robert Pruett en_US
dc.date.accessioned 2010-04-02T18:11:16Z
dc.date.available 2010-04-02T18:11:16Z
dc.date.issued 2007-03-28 en_US
dc.identifier.other etd-03212007-150136 en_US
dc.identifier.uri http://www.lib.ncsu.edu/resolver/1840.16/2210
dc.description.abstract North Carolina State University in conjunction with Bruce Technologies Inc. is developing recirculating water targets for the cyclotron production of high yields of 18F fluoride for PET radiopharmaceuticals. Flourine-18 is commonly produced through proton irradiation of 18O enriched water by the 18O(p,n)18F reaction. Heat deposited in the target fluid by the proton beam is proportional to the 18F produced, thus production is often limited by the targets ability to reject heat. For power levels above 3 kW, boiling batch targets with local cooling can become impractical due to excessive 18O water volumes. One potential solution is a recirculating target system where the target water velocity is sufficient to prevent boiling. In this design the heated fluid travels through an external heat exchanger of sufficient capacity to remove the heat, and then through a pump which returns the cooled fluid to the target. A high-flow/low-volume pump and a high-capacity/low-volume heat exchanger are essential to the overall performance of the recirculating target. In this work, two different types of heat exchangers are considered. Laboratory testing was conducted on a small shell and tube heat exchanger that removed nearly 6 kW of heat at flows provided by a miniature regenerative turbine pump. Laboratory testing was also conducted on a small cross flow heat exchanger with measured performance of 7.4 kW and predicted peak performance approaching 10 kW. en_US
dc.rights I hereby certify that, if appropriate, I have obtained and attached hereto a written permission statement from the owner(s) of each third party copyrighted matter to be included in my thesis, dis sertation, or project report, allowing distribution as specified below. I certify that the version I submitted is the same as that approved by my advisory committee. I hereby grant to NC State University or its agents the non-exclusive license to archive and make accessible, under the conditions specified below, my thesis, dissertation, or project report in whole or in part in all forms of media, now or hereafter known. I retain all other ownership rights to the copyright of the thesis, dissertation or project report. I also retain the right to use in future works (such as articles or books) all or part of this thesis, dissertation, or project report. en_US
dc.subject cyclotron en_US
dc.subject radiopharmaceuticals en_US
dc.subject radioisotope production en_US
dc.subject 18F anion en_US
dc.subject 2-deoxy-2-[18F]fluoro-D-glucose en_US
dc.subject High power density heat exchangers en_US
dc.subject high efficiency heat exchangers en_US
dc.subject 18FDG en_US
dc.title High Capacity Heat Exchangers for Recirculating 18F Radionuclide Production Targets en_US
dc.degree.name MS en_US
dc.degree.level thesis en_US
dc.degree.discipline Nuclear Engineering en_US


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