Development of Methodology to Synthesize (S)-Nicotine Derivatives

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Title: Development of Methodology to Synthesize (S)-Nicotine Derivatives
Author: King, Laura Stuart
Advisors: Dr.Carl Bumgardner, Committee Member
Dr. Daniel L. Comins, Committee Chair
Dr.Jon Lindsey, Committee Member
Abstract: N-acylpyridinium salt chemistry was used to synthesize 4 substituted (S)-nicotine derivatives. The intermediate dihydronicotines and resulting nicotine derivatives serve as potential pharmaceutical and pesticide targets as well as interesting synthetic intermediates. Other methodologies developed synthesize (s)-nicotine-N-oxide.
Date: 2004-02-12
Degree: MS
Discipline: Chemistry

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