Vascular Tissue Engineering Scaffolds from Elastomeric Biodegradable Poly(L-lactide-co-epsilon-caprolactone)(PLCL) via Melt spinning and Electrospinning

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dc.contributor.advisor Martin W. King, Committee Chair en_US
dc.contributor.advisor Hechmi Hamouda, Committee Member en_US
dc.contributor.advisor Stephen Michielsen, Committee Member en_US
dc.contributor.author Chung, Sangwon en_US
dc.date.accessioned 2010-04-02T18:15:35Z
dc.date.available 2010-04-02T18:15:35Z
dc.date.issued 2006-04-26 en_US
dc.identifier.other etd-03292006-025436 en_US
dc.identifier.uri http://www.lib.ncsu.edu/resolver/1840.16/2584
dc.description.abstract Three dimensional scaffolds play an important role in tissue engineering as a matrix that provides the cells with a tissue specific environment and architecture. For cardiovascular applications in particular, the development of elastic scaffolds that can maintain their mechanical integrity while being exposed to cyclic mechanical strains is a necessary criterion. The main objective of this study was to demonstrate the feasibility of fabricating vascular tissue engineering scaffolds via two different approaches, namely; melt spinning and electrospinning from elastomeric biodegradable poly(L-lactide-co-ε-caprolactone) (PLCL) copolymers. Overall, the tubular scaffolds had porosity exceeding 70% and the mechanical properties exceeded the transverse tensile values of the natural arteries of similar caliber. The morphology was also characterized as well as the fiber diameters and the pore sizes of the structures. In addition to spinning the polymer separately into melt spun and electrospun constructs, the novel approach in this study has been to successfully demonstrate that these two techniques can be combined to produce a two layered tubular scaffold containing both melt spun fibers and electrospun nanofibers. en_US
dc.rights I hereby certify that, if appropriate, I have obtained and attached hereto a written permission statement from the owner(s) of each third party copyrighted matter to be included in my thesis, dissertation, or project report, allowing distribution as specified below. I certify that the version I submitted is the same as that approved by my advisory committee. I hereby grant to NC State University or its agents the non-exclusive license to archive and make accessible, under the conditions specified below, my thesis, dissertation, or project report in whole or in part in all forms of media, now or hereafter known. I retain all other ownership rights to the copyright of the thesis, dissertation or project report. I also retain the right to use in future works (such as articles or books) all or part of this thesis, dissertation, or project report. en_US
dc.subject Nanofibers en_US
dc.subject PLCL en_US
dc.subject Melt spinning en_US
dc.subject Tissue engineering scaffolds en_US
dc.subject Electrospinning en_US
dc.title Vascular Tissue Engineering Scaffolds from Elastomeric Biodegradable Poly(L-lactide-co-epsilon-caprolactone)(PLCL) via Melt spinning and Electrospinning en_US
dc.degree.name MS en_US
dc.degree.level thesis en_US
dc.degree.discipline Textile and Apparel, Technology and Management en_US


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