Direct Detection of Microcalcification Pairs in Simulated Digital Mammograms

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dc.contributor.advisor R. Eugene Johnston, Committee Member en_US
dc.contributor.advisor Kuruvilla Verghese, Committee Chair en_US
dc.contributor.advisor Zhilin Li, Committee Member en_US
dc.contributor.advisor J. Michael Doster, Committee Member en_US
dc.contributor.advisor Douglas E. Peplow, Committee Member en_US Zeigler, Gary Boyce en_US 2010-04-02T18:18:17Z 2010-04-02T18:18:17Z 2002-10-31 en_US
dc.identifier.other etd-09302002-095022 en_US
dc.description.abstract Using the MCMIS (Monte Carlo for Mammography Image Simulation) code, several possible scenarios of microcalcification images were simulated for the Fischer Senoscan™ digital mammography system, which has been approved for clinical use by the F.D.A. The cases simulated included detectors that have 100 μm x 100 μm, 50 μm x 50 μm, and 25 μm x 25 μm pixels in order to determine how much improvement can be obtained through decreased pixel size in the detection of microcalcification clusters in mammograms. Breast thickness was also varied for each modality from 4 to 7 cm in order to determine the effect that reduced breast compression will have on image quality under ideal conditions. The breast phantom used for each simulation included a region of microcalcification pairs of varying size and pair spacing. This microcalcification cluster phantom was designed such that simulated images would indicate the minimum required size and spacing for microcalcification clusters to become distinctly discernable in each of the modalities under scrutiny. Both qualitative and quantitative analyses were performed for each simulated image produced. A decrease in detector pixel size did not show the expected result of significant improvement in cluster detection ability, even under ideal conditions. However, for the range of breast thickness studied, results indicate that decreasing the amount of compression during a mammogram did not significantly affect the image quality in terms of image resolution or contrast for all detector modalities tested. These results suggest that new detector modalities incorporating smaller detector pixel sizes may not show significant improvement over current modalities. However, they also suggest that doctors may be able to make the mammogram process less painful for the patient while maintaining image quality. en_US
dc.rights I hereby certify that, if appropriate, I have obtained and attached hereto a written permission statement from the owner(s) of each third party copyrighted matter to be included in my thesis, dissertation, or project report, allowing distribution as specified below. I certify that the version I submitted is the same as that approved by my advisory committee. I hereby grant to NC State University or its agents the non-exclusive license to archive and make accessible, under the conditions specified below, my thesis, dissertation, or project report in whole or in part in all forms of media, now or hereafter known. I retain all other ownership rights to the copyright of the thesis, dissertation or project report. I also retain the right to use in future works (such as articles or books) all or part of this thesis, dissertation, or project report. en_US
dc.subject resolution en_US
dc.subject contrast en_US
dc.subject microcalcifications en_US
dc.subject mammography en_US
dc.title Direct Detection of Microcalcification Pairs in Simulated Digital Mammograms en_US MS en_US thesis en_US Nuclear Engineering en_US

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