Concurrent and Sequential Surface Modification of Electrospun Polymer Micro/Nano-Fibers

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dc.contributor.advisor Orlin D. Velev, Committee Member en_US
dc.contributor.advisor Tushar K. Ghosh, Committee Member en_US
dc.contributor.advisor Saad A. Khan, Committee Member en_US
dc.contributor.advisor Richard J. Spontak, Committee Chair en_US Sun, Xiaoyu en_US 2010-04-02T18:29:01Z 2010-04-02T18:29:01Z 2009-04-23 en_US
dc.identifier.other etd-03172008-185615 en_US
dc.description.abstract Surface modification of nano-fibers with bioactive functional groups has become an arresting research area in recent decades, which provides possibility for the invention of bioactive materials for textiles and biomedical applications e.g. tissue engineering. The major objective of this research is to develop a novel single-step processing route for the production of synthetic fibers possessing specific bioactive surface functionalities at nano/submicron scale. Unlike traditional sequential surface modification of nanofibers, sequence-defined oligo-peptide that carries biofunctionality was synthesized separately before incorporated onto the electrospun fibers as surface functionalities by a single-step spinning process, so as to avoid the effect from chemical synthesis on fiber processing. As one of the most widely-used technologies for the production of polymeric nanofibers, electrospinning was chosen to achieve the single-step surface modification. Conventional homopolymer in conjunction with the biofunctional oligopeptide-incorporated block copolymer were co-electrospun. Nanofibers at submicron scale with surface enrichment of block copolymer were achieved due to phase separation caused by polarizability difference under static electric field. The surface segregation of peptide block was proved by the nitrogen enrichment measured from X-ray Photoelectric Spectroscopy (XPS). The proposed mechanism is discussed based on mainly the model homopolymer system of polyethylene oxide (PEO), and extended to the ternary polymer blends composed of thermoplastic polymethyl methacrylate (PMMA), PEO and block copolymer. The surface modification technique introduced deep insight into the electrospinning process with its effect to the polymer blends microphase separation, and leads to a promising perspective for biomaterial engineers to produce nanofibers with certain surface bio-functional groups. en_US
dc.rights I hereby certify that, if appropriate, I have obtained and attached hereto a written permission statement from the owner(s) of each third party copyrighted matter to be included in my thesis, dis sertation, or project report, allowing distribution as specified below. I certify that the version I submitted is the same as that approved by my advisory committee. I hereby grant to NC State University or its agents the non-exclusive license to archive and make accessible, under the conditions specified below, my thesis, dissertation, or project report in whole or in part in all forms of media, now or hereafter known. I retain all other ownership rights to the copyright of the thesis, dissertation or project report. I also retain the right to use in future works (such as articles or books) all or part of this thesis, dissertation, or project report. en_US
dc.subject Polymer en_US
dc.subject Biomaterials en_US
dc.subject Nanofibers en_US
dc.subject Surface modification en_US
dc.subject Electrospinning en_US
dc.title Concurrent and Sequential Surface Modification of Electrospun Polymer Micro/Nano-Fibers en_US PhD en_US dissertation en_US Chemical Engineering en_US

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