The Study of N-Acylpyridinium SaltChemistry and Its Application in the Asymmetric Synthesis of Streptomyces SS20846A

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Title: The Study of N-Acylpyridinium SaltChemistry and Its Application in the Asymmetric Synthesis of Streptomyces SS20846A
Author: Homer, Holly K.
Advisors: Dr. Daniel L. Comins, Chair
Dr. Suzanne T. Purrington, Member
Dr. Binghe Wang, Member
Abstract: The first part of this research was directed towards a study of the mechanism of N-acylpyridinium salt chemistry. Comparison of de's obtained from organometallic additions to the pyridinium salt versus analogous non-organometallic additions would show whether chelation of the metals plays a key role in the mechanism. The second focus of this research was on the use of chiral N-acylpyridinium salt chemistry in the asymmetric synthesis of Streptomyces SS20846A, a natural product isolated from a soil sample in Greece which has a restrictive action on the digestive system.
Date: 2000-04-03
Degree: MS
Discipline: Chemistry
URI: http://www.lib.ncsu.edu/resolver/1840.16/531


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