Tree-structured Classification for Multivariate Binary Responses

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Title: Tree-structured Classification for Multivariate Binary Responses
Author: Wang, Jiuzhou
Advisors: Marc G. Genton, Committee Co-Chair
Leonard A. Stefanski, Committee Chair
S. Stanley Young, Committee Member
John F. Monahan, Committee Member
Abstract: In this work, a new algorithm of tree-structured classification for multivariate binary responses, the majority-vote method, is proposed. The majority-vote method is a variation of the original work of Breiman et al (1984) on Classification And Regression Trees. The majority-vote method is similar to CART in that both methods use node impurity as the basis of the splitting rules. The majority-vote method differs from CART in that it determines tree size by choosing an optimal threshold value so that the cross-validated hit rate is maximized, whereas CART uses cost-complexity pruning to determine the optimal tree size. The original motivation of this work is to handle incomplete data, missing and censoring, in a Quantitative Structure Activity Relationship (QSAR) context, where the responses are continuous measurements of activity levels. We proceed by discretizing the responses into binary variables and using the majority-vote method to analyze the resulting binary responses. The performance of the majority-vote method is compared to its continuous response counterpart, MultiSCAM, a tree-structured algorithm for analyzing multivariate continuous responses. Multivariate analysis of variance (MANOVA) is used to evaluate the relative information loss due to discretization. The predictivity of the majority-vote method is evaluated by hit rate, a commonly used criterion in drug discovery. Simulation studies show that the majority-vote method outperforms MultiSCAM for censored data in that it yields higher hit rates.
Date: 2003-12-19
Degree: PhD
Discipline: Statistics

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