The Interaction of Boronic Acid Based Self-Assembled Monolayers as a Potential Glucose Sensor

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Title: The Interaction of Boronic Acid Based Self-Assembled Monolayers as a Potential Glucose Sensor
Author: Allen, Angela M.
Advisors: Christopher Gorman, Committee Chair
Charles B. Boss, Committee Member
Edmond F. Bowden, Committee Member
Kenneth W. Hanck, Committee Member
Abstract: Recognition of sugars such as glucose with phenylboronic acid–terminated self assembled monolayers (SAMs) was the basis for the designing and fabricating a biosensor. Self-assembled monolayers were formed on gold surfaces as shown by infrared spectroscopy. The continuous, repeatable increase of the electrochemical impedance as the concentration of glucose was increased gave indication of binding. This binding could be attributed to the precedent formation of relatively stable esters between phenylboronic acids and sugars. This impedance change upon binding between glucose and a phenylboronic acid-terminated SAM showed promise in the development of a glucose biosensor.
Date: 2005-08-02
Degree: PhD
Discipline: Chemistry
URI: http://www.lib.ncsu.edu/resolver/1840.16/5801


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