PROGRESS TOWARD THE TOTAL SYNTHESIS OF 14-ISOAZACAMPTOTHECIN AND SYNTHESIS OF SUBSTITUTED QUINOLINES.

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dc.contributor.advisor Prof. Wendell W. Wilkerson, Committee Member en_US
dc.contributor.advisor Prof. Daniel L. Comins, Committee Chair en_US
dc.contributor.advisor Prof. Harold S. Freeman, Committee Member en_US
dc.contributor.advisor Prof. Jonathan S. Lindsey, Committee Member en_US
dc.contributor.advisor Prof. Bruce Novak , Committee Member en_US
dc.contributor.author Bori, Ibrahim Danlami en_US
dc.date.accessioned 2010-08-19T18:14:29Z
dc.date.available 2010-08-19T18:14:29Z
dc.date.issued 2010-07-09 en_US
dc.identifier.other etd-06112008-143128 en_US
dc.identifier.uri http://www.lib.ncsu.edu/resolver/1840.16/6183
dc.description.abstract BORI, IBRAHIM DANLAMI. Progress Toward the Total Synthesis of 14-Isoazacamptothecin, and Synthesis of Substituted Quinolines. (Under the direction of Professor Daniel Lee Comins.) Studies were conducted with the purpose of completing the first total synthesis of 14-isoazacamptothecin. During the courses of this endeavor, new insights into pyridine chemistry were uncovered. It was demonstrated for the first time that C-4 substitution of 2,5-dibromopyridine via C-4 lithiation is indeed possible. New reactions in heterocyclic chemistry, namely (a) “Halogen Dance-Lithium Migration-Halogen Dance†or “Lithium Migration-Halogen Dance†and (b) Double Halogen Dance†were discovered to have taken place as explanations for the observation of unexpected products. Synthetic methods toward the synthesis of new quinoline analogs using readily available and inexpensive starting materials were developed. Although the initial inspirational target of the project was the AB ring fragment of CPT analogs, new techniques and methods were developed that would be useful in far reaching applications such as in the synthesis of clinically useful compounds and natural products containing a quinoline ring in the parent structure. en_US
dc.rights I hereby certify that, if appropriate, I have obtained and attached hereto a written permission statement from the owner(s) of each third party copyrighted matter to be included in my thesis, dis sertation, or project report, allowing distribution as specified below. I certify that the version I submitted is the same as that approved by my advisory committee. I hereby grant to NC State University or its agents the non-exclusive license to archive and make accessible, under the conditions specified below, my thesis, dissertation, or project report in whole or in part in all forms of media, now or hereafter known. I retain all other ownership rights to the copyright of the thesis, dissertation or project report. I also retain the right to use in future works (such as articles or books) all or part of this thesis, dissertation, or project report. en_US
dc.subject Nigeria en_US
dc.subject CPT en_US
dc.subject 14-IsoazaCPT en_US
dc.subject Ikot Ansa en_US
dc.subject Calabar en_US
dc.title PROGRESS TOWARD THE TOTAL SYNTHESIS OF 14-ISOAZACAMPTOTHECIN AND SYNTHESIS OF SUBSTITUTED QUINOLINES. en_US
dc.degree.name PhD en_US
dc.degree.level dissertation en_US
dc.degree.discipline Chemistry en_US


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