Finite Element Analysis of an In Vitro Traumatic Joint Loading Model
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Date
2010-04-20
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Abstract
Osteoarthritis (OA) is characterized by the degeneration of articular cartilage
resulting in eventual bone on bone contact causing pain and inflammation to
musculoskeletal joints. An in vitro impact injury model that incorporated tangential
loading was developed in our lab using intact porcine patellae to produce quantifiable
degradation similar to that seen in early stage osteoarthritis. We carried out two separate
sets of in vitro impact experiments: (1) axial impactions: an impact insult normal to the
cartilage surface at a high load and relatively fast loading rate and (2) shear impactions:
a compressive preload normal to the surface subsequently followed by a tangentially
applied displacement generating a shear load. Cell death and matrix proteoglycan loss
were quantified. After validation of the finite element model and collection of
histological data, statistical analysis was used to correlate type, location and magnitude
of stress and strain with cell death and proteoglycan loss. The overall hypothesis was
that shear forces arising from traumatic impact injuries are more detrimental to cartilage
matrix and chondrocytes than axial forces normally seen in most impact injury models.
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Keywords
impact injury, cartilage, finite element analysis, osteoarthritis, hyperelastic material, cartilage degeneration
Citation
Degree
PhD
Discipline
Biomedical Engineering
