Statistical Studies of Genomics Data
| dc.contributor.advisor | Zhao-Bang Zeng, Committee Chair | en_US |
| dc.contributor.advisor | Bruce Weir, Committee Co-Chair | en_US |
| dc.contributor.advisor | Leonard Stefanski, Committee Member | en_US |
| dc.contributor.advisor | Hao Helen Zhang, Committee Member | en_US |
| dc.contributor.advisor | Russell Wolfinger, Committee Member | en_US |
| dc.contributor.author | Feng, Sheng | en_US |
| dc.date.accessioned | 2010-04-02T18:25:48Z | |
| dc.date.available | 2010-04-02T18:25:48Z | |
| dc.date.issued | 2004-12-28 | en_US |
| dc.degree.discipline | Statistics | en_US |
| dc.degree.level | dissertation | en_US |
| dc.degree.name | PhD | en_US |
| dc.description.abstract | In recent years, studies on Genetics and Genomics have become one of the most active fields in science. The Genetic and Genomics data have several significant and unique characteristics that bring great challenges for data analysis. Three statistical studies have been presented in this dissertation. In chapter 1, an empirical Bayesian approach has been developed in a linear mixed model for Microarray data analysis. In chapter 2, a multiple order Markov chain model is applied to summarize the local correlation patterns among multiple genetic markers in linkage disequilibrium mapping. In chapter 3, a shrinkage method is being developed to integrate Biological prior knowledge presented in moment statistics. This new method may be useful in some genetic network studies. | en_US |
| dc.identifier.other | etd-12152004-224312 | en_US |
| dc.identifier.uri | http://www.lib.ncsu.edu/resolver/1840.16/3012 | |
| dc.rights | I hereby certify that, if appropriate, I have obtained and attached hereto a written permission statement from the owner(s) of each third party copyrighted matter to be included in my thesis, dissertation, or project report, allowing distribution as specified below. I certify that the version I submitted is the same as that approved by my advisory committee. I hereby grant to NC State University or its agents the non-exclusive license to archive and make accessible, under the conditions specified below, my thesis, dissertation, or project report in whole or in part in all forms of media, now or hereafter known. I retain all other ownership rights to the copyright of the thesis, dissertation or project report. I also retain the right to use in future works (such as articles or books) all or part of this thesis, dissertation, or project report. | en_US |
| dc.subject | Microarray Data Analysis | en_US |
| dc.subject | Shrinkage method | en_US |
| dc.subject | Linkage Disequilibrium Mapping | en_US |
| dc.title | Statistical Studies of Genomics Data | en_US |
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