The Interaction of Boronic Acid Based Self-Assembled Monolayers as a Potential Glucose Sensor

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dc.contributor.advisorChristopher Gorman, Committee Chairen_US
dc.contributor.advisorCharles B. Boss, Committee Memberen_US
dc.contributor.advisorEdmond F. Bowden, Committee Memberen_US
dc.contributor.advisorKenneth W. Hanck, Committee Memberen_US
dc.contributor.authorAllen, Angela M.en_US
dc.date.accessioned2010-04-02T19:20:13Z
dc.date.available2010-04-02T19:20:13Z
dc.date.issued2005-08-02en_US
dc.degree.disciplineChemistryen_US
dc.degree.leveldissertationen_US
dc.degree.namePhDen_US
dc.descriptionNorth Carolina State University Theses Chemistry.
dc.description.abstractRecognition of sugars such as glucose with phenylboronic acid–terminated self assembled monolayers (SAMs) was the basis for the designing and fabricating a biosensor. Self-assembled monolayers were formed on gold surfaces as shown by infrared spectroscopy. The continuous, repeatable increase of the electrochemical impedance as the concentration of glucose was increased gave indication of binding. This binding could be attributed to the precedent formation of relatively stable esters between phenylboronic acids and sugars. This impedance change upon binding between glucose and a phenylboronic acid-terminated SAM showed promise in the development of a glucose biosensor.en_US
dc.formatThesis (Ph.D.)--North Carolina State University.
dc.identifier.otheretd-11302004-115753en_US
dc.identifier.urihttp://www.lib.ncsu.edu/resolver/1840.16/5801
dc.rightsI hereby certify that, if appropriate, I have obtained and attached hereto a written permission statement from the owner(s) of each third party copyrighted matter to be included in my thesis, dissertation, or project report, allowing distribution as specified below. I certify that the version I submitted is the same as that approved by my advisory committee. I hereby grant to NC State University or its agents the non-exclusive license to archive and make accessible, under the conditions specified below, my thesis, dissertation, or project report in whole or in part in all forms of media, now or hereafter known. I retain all other ownership rights to the copyright of the thesis, dissertation or project report. I also retain the right to use in future works (such as articles or books) all or part of this thesis, dissertation, or project report.en_US
dc.subjectbiosensorsen_US
dc.subjectboronic aciden_US
dc.subjectmonolayersen_US
dc.titleThe Interaction of Boronic Acid Based Self-Assembled Monolayers as a Potential Glucose Sensoren_US
dcterms.abstractKeywords: biosensors, boronic acid, monolayers.
dcterms.extentxvi, 95 pages : illustrations (some color)

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